Age-related macular degeneration (AMD) is one of the the leading causes of irreversible vision loss. .
Anyone can develop AMD, but lifestyle and diet are major factors in an individual's risk. And it's clear that genetic factors have a lot of influence on when AMD might start and how it progresses.
Variations in two genes have been more closely connected to both developing AMD and whether it progresses to the advanced stages of the disease. These are:
- the complement cascade (group of genes on chromosome 1; and
- the ARMS2/HTRA genes on chromosome 10.
The presence of these genetic variants doesn’t mean that someone will definitely develop AMD. These variants mean that one may have a higher risk of AMD or developing advanced disease in the future.
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